Effect of pepsin on erosive tissue loss and the efficacy of fluoridation measures in dentine in vitro.
Identifieur interne : 000415 ( Main/Exploration ); précédent : 000414; suivant : 000416Effect of pepsin on erosive tissue loss and the efficacy of fluoridation measures in dentine in vitro.
Auteurs : Nadine Schlueter [Allemagne] ; Carolina Ganss ; Martin Hardt ; Daniel Schegietz ; Joachim KlimekSource :
- Acta odontologica Scandinavica [ 1502-3850 ] ; 2007.
Descripteurs français
- KwdFr :
- Acide chlorhydrique (MeSH), Collagène (effets des médicaments et des substances chimiques), Collagène (métabolisme), Dent de sagesse (MeSH), Dentine (effets des médicaments et des substances chimiques), Dentine (ultrastructure), Déminéralisation dentaire (enzymologie), Fluorures (usage thérapeutique), Humains (MeSH), Hydroxyproline (analyse), Microscopie électronique à balayage (MeSH), Pepsine A (pharmacologie), Reminéralisation des dents (MeSH), Érosion dentaire (enzymologie), Érosion dentaire (traitement médicamenteux).
- MESH :
- analyse : Hydroxyproline.
- effets des médicaments et des substances chimiques : Collagène, Dentine.
- enzymologie : Déminéralisation dentaire, Érosion dentaire.
- métabolisme : Collagène.
- pharmacologie : Pepsine A.
- traitement médicamenteux : Érosion dentaire.
- usage thérapeutique : Dentine, Fluorures.
- Acide chlorhydrique, Dent de sagesse, Humains, Microscopie électronique à balayage, Reminéralisation des dents.
English descriptors
- KwdEn :
- Collagen (drug effects), Collagen (metabolism), Dentin (drug effects), Dentin (ultrastructure), Fluorides (therapeutic use), Humans (MeSH), Hydrochloric Acid (MeSH), Hydroxyproline (analysis), Microscopy, Electron, Scanning (MeSH), Molar, Third (MeSH), Pepsin A (pharmacology), Tooth Demineralization (enzymology), Tooth Erosion (drug therapy), Tooth Erosion (enzymology), Tooth Remineralization (MeSH).
- MESH :
- chemical , analysis : Hydroxyproline.
- chemical , drug effects : Collagen.
- chemical , metabolism : Collagen.
- drug effects : Dentin.
- drug therapy : Tooth Erosion.
- enzymology : Tooth Demineralization, Tooth Erosion.
- chemical , pharmacology : Pepsin A.
- chemical , therapeutic use : Fluorides.
- ultrastructure : Dentin.
- Humans, Hydrochloric Acid, Microscopy, Electron, Scanning, Molar, Third, Tooth Remineralization.
Abstract
OBJECTIVES
In dentine, erosive lesion progression and efficacy of fluoridation measures for symptomatic therapy of dental erosion are both dependent on the presence of the organic matrix. In patients with eating disorders in combination with chronic vomiting, the demineralized organic matrix can be degraded by gastric enzymes. The aim of this study was to investigate the effect of pepsin on erosion progression and the efficacy of fluoride in dentine.
MATERIAL AND METHODS
Human dentine specimens were prepared and randomly divided into 4 groups of 20 specimens each. They were subjected to a cyclic de- and remineralization procedure for 9 days. For demineralization (6 x 2 min per day), an HCl solution (pH 1.6) was used in all groups. In two groups, pepsin (1.5 mg mL(-1)) was added to the demineralization solution. Fluoridation was performed in two groups 6 x 1 min per day with a mouth rinse (Olaflur/SnF(2); 250 ppm F(-)) after demineralization with both the HCl solution and the pepsin containing solution. Degradation of collagen was quantified by analyzing hydroxyproline and tissue loss was determined microradiographically. SEM images were taken in addition.
RESULTS
In the pepsin group, 1.72 (0.26) microg mL(-1) (mean (SD)) hydroxyproline per day was detected, and in the pepsin-fluoride group 1.95 (0.50) microg mL(-1). Tissue loss after 9 days in the control group was similar to that in the pepsin group (122.2 (53.4) microm and 122.2 (38.0) microm, n.s., respectively). Fluoridation reduced tissue loss after demineralization (98.8 (30.2) microm) but not after pepsin treatment (125.2 (34.2) microm; p< or =0.05).
CONCLUSION
Under the conditions used, pepsin had no influence on tissue loss, but altered the efficacy of fluoridation measures.
DOI: 10.1080/00016350701678733
PubMed: 18092202
Affiliations:
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Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Ganss, Carolina" sort="Ganss, Carolina" uniqKey="Ganss C" first="Carolina" last="Ganss">Carolina Ganss</name></author><author><name sortKey="Hardt, Martin" sort="Hardt, Martin" uniqKey="Hardt M" first="Martin" last="Hardt">Martin Hardt</name></author><author><name sortKey="Schegietz, Daniel" sort="Schegietz, Daniel" uniqKey="Schegietz D" first="Daniel" last="Schegietz">Daniel Schegietz</name></author><author><name sortKey="Klimek, Joachim" sort="Klimek, Joachim" uniqKey="Klimek J" first="Joachim" last="Klimek">Joachim Klimek</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="RBID">pubmed:18092202</idno><idno type="pmid">18092202</idno><idno type="doi">10.1080/00016350701678733</idno><idno type="wicri:Area/Main/Corpus">000402</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000402</idno><idno 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type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Collagen (drug effects)</term><term>Collagen (metabolism)</term><term>Dentin (drug effects)</term><term>Dentin (ultrastructure)</term><term>Fluorides (therapeutic use)</term><term>Humans (MeSH)</term><term>Hydrochloric Acid (MeSH)</term><term>Hydroxyproline (analysis)</term><term>Microscopy, Electron, Scanning (MeSH)</term><term>Molar, Third (MeSH)</term><term>Pepsin A (pharmacology)</term><term>Tooth Demineralization (enzymology)</term><term>Tooth Erosion (drug therapy)</term><term>Tooth Erosion (enzymology)</term><term>Tooth Remineralization (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide chlorhydrique (MeSH)</term><term>Collagène (effets des médicaments et des substances chimiques)</term><term>Collagène (métabolisme)</term><term>Dent de sagesse (MeSH)</term><term>Dentine (effets des médicaments et des substances chimiques)</term><term>Dentine (ultrastructure)</term><term>Déminéralisation dentaire (enzymologie)</term><term>Fluorures (usage thérapeutique)</term><term>Humains (MeSH)</term><term>Hydroxyproline (analyse)</term><term>Microscopie électronique à balayage (MeSH)</term><term>Pepsine A (pharmacologie)</term><term>Reminéralisation des dents (MeSH)</term><term>Érosion dentaire (enzymologie)</term><term>Érosion dentaire (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Hydroxyproline</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Collagen</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Collagen</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Hydroxyproline</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Dentin</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Tooth Erosion</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Collagène</term><term>Dentine</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Déminéralisation dentaire</term><term>Érosion dentaire</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Tooth Demineralization</term><term>Tooth Erosion</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Collagène</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Pepsine A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Pepsin A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Fluorides</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Érosion dentaire</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Dentin</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Dentine</term><term>Fluorures</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Hydrochloric Acid</term><term>Microscopy, Electron, Scanning</term><term>Molar, Third</term><term>Tooth Remineralization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acide chlorhydrique</term><term>Dent de sagesse</term><term>Humains</term><term>Microscopie électronique à balayage</term><term>Reminéralisation des dents</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>In dentine, erosive lesion progression and efficacy of fluoridation measures for symptomatic therapy of dental erosion are both dependent on the presence of the organic matrix. In patients with eating disorders in combination with chronic vomiting, the demineralized organic matrix can be degraded by gastric enzymes. The aim of this study was to investigate the effect of pepsin on erosion progression and the efficacy of fluoride in dentine.</p></div><div type="abstract" xml:lang="en"><p><b>MATERIAL AND METHODS</b></p><p>Human dentine specimens were prepared and randomly divided into 4 groups of 20 specimens each. They were subjected to a cyclic de- and remineralization procedure for 9 days. For demineralization (6 x 2 min per day), an HCl solution (pH 1.6) was used in all groups. In two groups, pepsin (1.5 mg mL(-1)) was added to the demineralization solution. Fluoridation was performed in two groups 6 x 1 min per day with a mouth rinse (Olaflur/SnF(2); 250 ppm F(-)) after demineralization with both the HCl solution and the pepsin containing solution. Degradation of collagen was quantified by analyzing hydroxyproline and tissue loss was determined microradiographically. SEM images were taken in addition.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>In the pepsin group, 1.72 (0.26) microg mL(-1) (mean (SD)) hydroxyproline per day was detected, and in the pepsin-fluoride group 1.95 (0.50) microg mL(-1). Tissue loss after 9 days in the control group was similar to that in the pepsin group (122.2 (53.4) microm and 122.2 (38.0) microm, n.s., respectively). Fluoridation reduced tissue loss after demineralization (98.8 (30.2) microm) but not after pepsin treatment (125.2 (34.2) microm; p< or =0.05).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Under the conditions used, pepsin had no influence on tissue loss, but altered the efficacy of fluoridation measures.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18092202</PMID><DateCompleted><Year>2008</Year><Month>01</Month><Day>15</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1502-3850</ISSN><JournalIssue CitedMedium="Internet"><Volume>65</Volume><Issue>5</Issue><PubDate><Year>2007</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Acta odontologica Scandinavica</Title><ISOAbbreviation>Acta Odontol Scand</ISOAbbreviation></Journal><ArticleTitle>Effect of pepsin on erosive tissue loss and the efficacy of fluoridation measures in dentine in vitro.</ArticleTitle><Pagination><MedlinePgn>298-305</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">In dentine, erosive lesion progression and efficacy of fluoridation measures for symptomatic therapy of dental erosion are both dependent on the presence of the organic matrix. In patients with eating disorders in combination with chronic vomiting, the demineralized organic matrix can be degraded by gastric enzymes. The aim of this study was to investigate the effect of pepsin on erosion progression and the efficacy of fluoride in dentine.</AbstractText><AbstractText Label="MATERIAL AND METHODS" NlmCategory="METHODS">Human dentine specimens were prepared and randomly divided into 4 groups of 20 specimens each. They were subjected to a cyclic de- and remineralization procedure for 9 days. For demineralization (6 x 2 min per day), an HCl solution (pH 1.6) was used in all groups. In two groups, pepsin (1.5 mg mL(-1)) was added to the demineralization solution. Fluoridation was performed in two groups 6 x 1 min per day with a mouth rinse (Olaflur/SnF(2); 250 ppm F(-)) after demineralization with both the HCl solution and the pepsin containing solution. Degradation of collagen was quantified by analyzing hydroxyproline and tissue loss was determined microradiographically. SEM images were taken in addition.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In the pepsin group, 1.72 (0.26) microg mL(-1) (mean (SD)) hydroxyproline per day was detected, and in the pepsin-fluoride group 1.95 (0.50) microg mL(-1). Tissue loss after 9 days in the control group was similar to that in the pepsin group (122.2 (53.4) microm and 122.2 (38.0) microm, n.s., respectively). Fluoridation reduced tissue loss after demineralization (98.8 (30.2) microm) but not after pepsin treatment (125.2 (34.2) microm; p< or =0.05).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Under the conditions used, pepsin had no influence on tissue loss, but altered the efficacy of fluoridation measures.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schlueter</LastName><ForeName>Nadine</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Conservative and Preventive Dentistry, Dental Clinic of Justus-Liebig-University Giessen, Germany. nadine.schlueter@dentist.med.uni-giessen.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ganss</LastName><ForeName>Carolina</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Hardt</LastName><ForeName>Martin</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Schegietz</LastName><ForeName>Daniel</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Klimek</LastName><ForeName>Joachim</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Acta Odontol Scand</MedlineTA><NlmUniqueID>0370344</NlmUniqueID><ISSNLinking>0001-6357</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>9007-34-5</RegistryNumber><NameOfSubstance UI="D003094">Collagen</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.23.1</RegistryNumber><NameOfSubstance UI="D010434">Pepsin A</NameOfSubstance></Chemical><Chemical><RegistryNumber>Q80VPU408O</RegistryNumber><NameOfSubstance UI="D005459">Fluorides</NameOfSubstance></Chemical><Chemical><RegistryNumber>QTT17582CB</RegistryNumber><NameOfSubstance 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MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006851" MajorTopicYN="N">Hydrochloric Acid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006909" MajorTopicYN="N">Hydroxyproline</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008855" MajorTopicYN="N">Microscopy, Electron, Scanning</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008964" MajorTopicYN="N">Molar, Third</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010434" MajorTopicYN="N">Pepsin A</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017001" MajorTopicYN="N">Tooth Demineralization</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014077" MajorTopicYN="N">Tooth Erosion</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014089" MajorTopicYN="N">Tooth Remineralization</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>12</Month><Day>20</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>1</Month><Day>16</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>12</Month><Day>20</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18092202</ArticleId><ArticleId IdType="pii">788638368</ArticleId><ArticleId 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